Document Type : Original Article
Authors
1
1Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Cairo, Egypt
2
2 Animal Reproduction Research Institute Agricultural Research Center, Giza, Egypt
3
3Therapeutic Nutrition Department, Faculty of Nutrition Science. Helwan University, Cairo, Egypt
Abstract
ABSTRACT
The present work aimed to investigate the effect of ashwagandha root powder (ARP) administrative by diabetic male rats. Thirty male rats were randomly divided into 5 equal groups (n=6). The 1st group was fed the basal diet for 56 days as a negative control (-ve). The 2nd group injected with a single dose of Alloxan to induce diabetes. Groups 3-5 as the same of group two but fed on basal diet containing 4, 6 and 8% of ARP, respectively. Results of chemical composition of ARP showed that each 100 g contained fat, fiber, protein, carbohydrate, ash and moisture at 0.9, 33.3, 3.3, 51.1, 4.2 and 7.2%, respectively. Polyphenolic compounds, Quercetin recorded 22.776 mg/100g, followed by Vanillic acid 18.66 mg/100g. The antioxidant activity DPPH was 63.69 % in the high tested level 7% of sample. Biological study showed that, administration of ARP to diabetic rats decreased weight gain, blood glucose level, TC, TG, LDL and MDA. On the other hand, levels of serum Insulin, HDL-c and CAT, were increased by ARP administration. In conclusion, dietary supplementation with ashwagandha root powder (ARP) resulted in a significant improvement in biomarkers associated with diabetes and hypercholesterolemia. These findings suggest that the intake of ARP may offer potential benefits for individuals with diabetes.
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