Hepatorenal Effect of Truffle on Oxidative Stress in Male Albino Rats

Document Type : Original Article

Authors

1 1-Nutrition and Food Sciences Department., Faculty of Home Economics, Helwan University, Cairo Egypt.

2 2- Home economics Dept., Faculty of Specific Education, Ain Shams University, Cairo, Egypt

Abstract

This research was conducted in order to examine the efficacy of truffle on eliminating oxidative stress of male albino rats. Thirty-six male rats were divided into six groups (6 rats of each) as follow; The 1st was fed on basal diet as a negative control group, the 2nd was as the same of group 1 and was intraperitoneally injected with potassium dichromate at a dose 10mg/kg BW as a positive control group, the 3rd, 4th and 5th as the same of group 2 with 300, 400 and 500 mg hydroethanolic truffle dried extract/Kg BW. Whereas, the 6th group as the same of group 2 with 500 mg truffle powder /Kg BW. At the end of experiment (after 8 weeks), rats were fasted over night before scarifying. Serum kidney and liver functions, oxidative and anti-oxidative markers were analysed. Kidney and liver were removed from each rat to histopathological examination. The results indicated that truffle extract or its powder caused significant decreased (P˂0.05) in serum CR, urea, AST, ALT, ALP and MDA but significant increase in CAT compared to the +ve control group. Otherwise, histopathological examination showed improvement on kidney and liver of groups treated with truffle extract( as concentration 500mg group 5) or its powder(as concentration 500mg group 6) compared with +ve control group. According to these above results, the usage of truffle extract or its powder as natural agent may be effective in reducing the risk of oxidative stress so may be play a therapeutic role of human beings.

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