Effect of Bisphenol A on Nephrotoxicity in Rats and The protective Role of Giloy and Echinacea Against This Effect

Document Type : Original Article

Authors

Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University Tanta, Egypt.

10.21608/enj.2025.373830.1106

Abstract

The BPA present in the
polycarbonate plastics and epoxy resins moves from the packaging material to the
dairy products eventually and caused toxicity .So that; this study aimed to investigate
the potential protective effect of Giloy (Tinospora cordifolia) (T.
cordifolia) and Echinacea (Echinacea purpurea ;E. purpurea), on nephrotoxicity in
experimental rats. Thirty six male albino rats (50±10 g) were randomly assigned to 6
equal groups (6 rats each), the first kept as as a negative control group (-v) control
received basal diet throughout the experimental period . While second was positive
control group (+v) control which treated orally with BPA (25 mg/kg/day) dissolved in
olive oil, to induce nephrotoxicity once daily, for 6 weeks while the four others
groups fed on basal diet and treated orally with BPA (25 mg/kg/day) and ethanolic
extracts of T. cordifolia (200, 400 mg/kg/day) and E. purpurea (200, 400mg/kg/day)
for 6 weeks ( as a protective experiment ) . At the end of experimental period,
biological evaluation, serum antioxidant enzymes, kidney function, Na, K were
evaluated and MDA were estimated. Also histological changes of kidney tissues were
examined. The obtained results concluded that supplemented diets with plant materials
(extract of T. cordifolia and E. purpurea) improved antioxidant enzymes status,
kidney function, Na, K and MDA. The best results found in high doses of T.
cordifolia and E. purpurea followed by low doses of T. cordifolia and E. purpurea.
So, these plants could be used for improves nephrotoxicity and may be other kidney
functions.

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Egyptian Journal of Nutrition
Volume 40, Issue 1
March 2025
Pages 119-140

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