Effect of Sodium Alginate ,Propolise and Carob Seeds Powder on Hypercholosterolemic Albino Rats

Abstract
 
This investigation was conducted to explore the protective effect of sodium alginate, propolis and carob seeds,for hypercholesterolemic and atherosclerotic rats.  to improve the blood glucose level , the lipids profile Total triglycerides (TG) Total Cholesterol (TC),Atherogenic index(AI), Low density lipoprotein Cholesterol(LDL-c)-High density lipoprotein Cholesterol(HDL-c),Very low density lipoprotein Cholesterol (VLDL-c),and some other physiological characteristics such as the liver function Aspartate transaminas (AST),Alanine transaminase (ALT)and Alkaline phosphatase(ALP), kidneys functions (uric acid, urea nitrogen and creatinine) , in addition to  the Body weight gain% (B.W.G), Food intake(FI) and weight of internal organs. Twenty five(25) male mature albino rats  were used and divided into  five main groups ,(5 rats  each group), one of them used as control -ve while other groups had  given 1.5%  pure cholesterol plus 10% sheep tail fat for 15 days. One of these groups left as control+ve, and other groups each fedon sodium alginate , propolis and carob seeds powder , at doses of 500 mg /kg B. W. for 42 days. Such treatments lowered the TC, TG, VLDL-c, LDL-c, & AI, while raised the HDL-c. Also, colloids diets reduced serum glucose, AST, ALT, ALP. The histopatholgical changes were; in line with the biochemical changes. Moreover, colloids treatment improved the Feed efficienncy ratio (FER). Therefore, the study recommends that the colloids can be used in the treatment of the hypercholesterolemia. The food, should tend to invent prouducts with colloids, specially the carob powder that easily (can be) added to baking goods .Similarly sodium alginate &propolis may be blended with foods.