Effect of Turmeric and Arabic Gum Supplementation on Liver Enzymes and Liver Antioxidant Enzymes in Rats Suffering from Glycerol Toxicity

ABSTRACT
This study aimed to investigate the effects of turmeric and gum Arabic supplementation on feed intake, some organ weight/ body weight%, liver enzymes, and liver antioxidant enzymes in rats suffering from glycerol toxicity. Sixty-six male albino rats of the Sprague-Dawley strain, weighing 150 + 10g, were used in this study. The rats in this study were divided into two main groups. The first main group (6 rats) was fed a basal diet (BD) as a control negative group (-ve). The second main group (60 rats) was divided into ten subgroups (6 rats each). The rats in the second main group were fed as follows: Subgroup (1): fed on a basal diet (BD) only as a control positive group (+ve). Subgroups (2, 3, and 4) were fed BD containing 1, 2, and 4 g of gum arabic (GA) per100 g of diet, respectively. Subgroups (5, 6, and 7) were fed BD containing 1, 2, and 4 g of turmeric per 100 g of diet, respectively. Subgroup (8) was fed BD containing 1 g of GA and 1g of turmeric per 100 g of diet. Subgroup (9) was fed BD containing 2 g of GA and 2g of turmeric per 100 g of diet. Subgroup (10) was fed BD containing 4 g of GA and 4g of turmeric per100 g of diet. Rats were fed on these diets for 28 days before and after 3 days' injection with glycerol to induce toxicity and acute renal failure. The results indicated that glycerol decreased feed intake, and increased liver &kidney weight/body weight%. Serum results revealed that aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphates (ALP) were increased by injection of rats with glycerol, as compared to non-injected rats. Liver results revealed that glutathione (GSH), and glutathione peroxidase (GPX) activities decreased, while malondialdehyde (MDA) activity increased, as compared to the negative control group. Treating rats that were suffering from kidney alteration induced by glycerol with tested diets improved all of these parameters, as compared to non-treated rats, especially the groups that were fed a diet containing a mixture of gum Arabic and turmeric with high level. Conclusion: gum Arabic, turmeric and their combination can be used to reduce the side effects of liver problems causing by kidney diseases. Therefore, intake of gum Arabic and turmeric may be beneficial for kidney and liver diseases patients.