Effect some germinated on nonalcoholic fatty liver disease in albino rats

other percentages of Egyptian J. Nutrition Vol. XXXIII No.3 (2018) Effect some germinated on nonalcoholic fatty liver disease in albino rats *Mohamed Samir EL-Dashluty, *Fatma EI-Zahraa EI-Shrief, Soliman, **Ahmed Sayed Khedr of Home Minoufiya University **National Nutrition Institute, Cairo, Egypt Abstract research aimed to the effect of pumpkin, and quinoa powder on nonalcoholic fatty liver (NAFLO) in rats. Seeds of pumpkin, lentil and quinoa were germinated, oven dried and analyzed for their nutritive value of their macronutrients, mineral, phenols & compounds contents. Sixty Albino Rats were into 10 groups. Negative control group was fed on basal diet. groups were fed for four weeks on higl'1fructose diet (HFD) to induce One of them is positive control group. NALFO were fed on mixed with seeds powders of pumpkin, lentil quinoa and their Biochemical of the rats' serum was done at the beginning and at the end of study for lipid [Total (TC) , triglycerides HOL-C, LOL­ I C&VLOL-C] , Liver enzymes(AST& ALT) , serum , blood urea & uric acid . Also, histopathological examination liver tissues analysis of the germinated were done. showed various germinated powders in 33

Mohamed Samir EL-Dashluty, Fatma EI-Zahraa EI-Shrief, Fardous Soliman, and Ahmed Sayed Khedr NAFLD led to improvement in lipid liver enzymes, creatinine and uric acid especially in group fed on 10% pumpkin, followed by groups 10% mix (pumpkin, lentil and quinoa) and 10% quinoa, respectively. These improvements happened in parallel with in liver were checked by microscopic examination. Compositional analysis of germinated revealed their photochemical compounds' contents that may beyond their favorable effects on the liver. Conclusion germinated pumpkin, lentil and quinoa improve both liver functions and liver of NAFLD rats. Introduction Liver function can be impaired and hepatocytes damaged upon to drugs, alcohol, infections, or malnutrition (Mroueh et a/., 2004). Nonalcoholic fatty liver disease (NAFLD), besides increasing liver morbidity and mortality, is with development atherosclerosis. Dyslipidemia and chronic inflammation are to drive development of NAFLD as well as atherosclerosis (Armstrong et a/., 2014). However, foods rich in have proposed as a tool to prevent cure liver damage (Morisco et a/., 2008). Sprouts' contents of nutrients; phytochemicals, vitamins, minerals, enzymes and amino are of almost importance for human health (Finley, 2005). 34