The Effect of Using Walnut Leaves, Iodine and Selenium to Improve Hypothyroidism for Thyroid Hormone in Rats.

Abstract
 
Thyroid hormones are essential for normal growth and development. Nutritional factors are closely related to thyroid dysfunction due to deviation from normal physiology of the gland. Iodine, is the main constituent of thyroid hormones (T3 and T4), deficiency is one of the commonest causes of hypothyroidism in children and adults, worldwide. Therefore, the aim of the research is to study the effect of walnut leaves, iodine and selenium, either alone or with their mixtures, on improving hypothyroidism in rats versus the drug effect of thyroid hormone. To achieve this goal present study was performed to examine the effect of walnut leaves, iodine and selenium consumption on thyroid hormones (T3,T4 and TSH) on hypothyroidism rats induced by Propylthiouracil at a dose of 10 mg / kg bw one time a day for two weeks. This work was carried out on 54 adult male albino rats randomly classified into nine groups, for each (n = 6). Group 1 (negative control) fed on basal diet. The major groups consisting of 48 rats were injected with Propylthiouracil, then divided into eight subgroups. subgroup (1) fed on basal diet (positive control group), sub group (2)fed on basal diet +10 mg thyroxin, subgroup (3)fed on basal diet + 10 μg selenium, subgroup (4)fed on basal diet + 10 μg iodine, subgroup (5)fed on basal diet + 10 mg walnut leaves, subgroup (6) fed on basal diet +5 mg walnut leaves and 5 mg thyroxin, subgroup (7)fed on basal diet + 5 mg walnut leaves+5 μg selenium, subgroup (8)feed on basal diet + 5 mg walnut leaves+5 μg iodine. The results showed that the groups that took walnut leaves powder, either alone or in combination with thyroxine, iodine, and selenium were significantly higher in the rate of recovery from hypothyroidism.,